Grelina (Total) - RIE
Descrição: Ghrelin (TOTAL) RIA
Informação: Grelina (Ghrelin) é um peptídeo acilado que estimula a liberação do hormônio do crescimento pela hipófise. Foi isolada de estômago de rato e sua estrutura foi determinada como um peptídeo pequeno de 28 aminoácidos pelo Dr. kenji Kangawa (National Cardiovascular Center in Japan). O resíduo Ser3 da Grelina é modificado pelo ácido-n-octanóico, modificação necessária para a atividade hormonal. A Grelina controla a fome e perda e ganho de peso a longo prazo.
Aplicações:
Dois dias de ensaio de desiquilíbrio a 4°C. Volume de amostra: < 100 µL Plasma (coletado em gelo)
Reatividade: Humano
Precisão, %:
- Inter-ensaio: 14.7–17.8
- Intra-ensaio: 3.3–10.0
Sensibilidade:100–10,000 pg/mL
Áreas terapêuticas:
- Diabetes
- Obesidade
- Desordem Metabólica
Exatidão: 90–96%
Linearidade de Diluição: 99–146%
Desempenho:
- ED80 = 395 ± 88 pg/mL
- ED50 = 895 ± 177 pg/mL
- ED20 = 2015 ± 382 pg/mL
Proteína: Ghrelin
DOCUMENTO
REFERÊNCIA DE PUBLICAÇÕES PARA ESTE KIT
- Basal Plasma Levels of Insulin, Leptin, Ghrelin, and Amylin Do Not Signal Adiposity in Rats Recovering from Forced Overweight.
Gloy VL, Lutz TA, Langhans W, Geary N, Hillebrand JJ (2010) Endocrinology - Comparison of Competitive Radioimmunoassays and Two-Site Sandwich Assays for the Measurement and Interpretation of Plasma Ghrelin Levels.
Prudom C, Liu J, Patrie J, Gaylinn BD, Foster-Schubert KE, Cummings DE, Thorner MO, Geysen HM (2010) The Journal of clinical endocrinology and metabolism - Metabolic maturity at birth and neonate lamb survival: association among maternal factors, litter size, lamb birth weight, and plasma metabolic and endocrine factors on survival and behavior.
Miller DR, Blache D, Jackson RB, Downie EF, Roche JR (2010) Journal of animal science.88:581-593 - Evaluation of the effect of four fibers on laxation, gastrointestinal tolerance and serum markers in healthy humans.
Stewart ML, Nikhanj SD, Timm DA, Thomas W, Slavin JL (2010) Annals of nutrition & metabolism.56:91-98 - Effect of overweight on gastrointestinal microbiology and immunology: correlation with blood biomarkers.
Tiihonen K, Ouwehand AC, Rautonen N (2009) The British journal of nutrition:1-9 - Metabolic maturity at birth and neonate lamb survival and growth: the effects of maternal low-dose dexamethasone treatment.
D R Miller, R B Jackson, D Blache, J R Roche (2009) Journal of animal science.87:3167-78 - Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment.
Abdullah Onder Barim, Suleyman Aydin, Ramis Colak, Ersel Dag, Omer Deniz, Ibrahim Sahin (2009) Clinical biochemistry.42:1076-81 - Appetite responds to changes in meal content, whereas ghrelin, leptin, and insulin track changes in energy availability.
Borer, Katarina T, et al. (2009) J. Clin. Endocrinol. Metab., 94: 2290-8 (2009) - Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader-Willi syndrome.
Kathleen De Waele, Stacey L Ishkanian, Roberto Bogarin, Charmaine A Miranda, Mohammad A Ghatei, Stephen R Bloom, Danièle Pacaud, Jean-Pierre Chanoine (2008) European journal of endocrinology / European Federation of Endocrine Societies.159:381-8 - Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest.
Gianni Biolo, Francesco Agostini, Bostjan Simunic, Mariella Sturma, Lucio Torelli, Jean Charles Preiser, Ginette Deby-Dupont, Paolo Magni, Felice Strollo, Pietro di Prampero, Gianfranco Guarnieri, Igor B Mekjavic, Rado Pisot, Marco V Narici (2008) The American journal of clinical nutrition.88:950-8 - High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring.
Ignatius M Y Szeto, Alfred Aziz, Paul J Das, Ameer Y Taha, Nobuhiko Okubo, Sandra Reza-Lopez, Adria Giacca, G Harvey Anderson (2008) American journal of physiology. Regulatory, integrative and comparative physiology.295:R575-82 - Presence of obestatin in breast milk: relationship among obestatin, ghrelin, and leptin in lactating women.
Suleyman Aydin, Yusuf Ozkan, Fazilet Erman, Bilgin Gurates, Nermin Kilic, Ramis Colak, Tugba Gundogan, Zekiye Catak, Mahmut Bozkurt, Okhan Akin, Yasar Sen, Ibrahim Sahn (2008) Nutrition (Burbank, Los Angeles County, Calif.).24:689-93 - Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene.
Irene V Lambrinoudaki, George E Christodoulakos, Emmanuel V Economou, Sofia A Vlachou, Constantinos P Panoulis, Andreas P Alexandrou, Evangelia E Kouskouni, George C Creatsas (2008) Maturitas.59:62-71 - Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa.
Anja W Dynesen, Allan Bardow, Arne Astrup, Birgit Petersson, Jens J Holst, Birgitte Nauntofte (2008) The American journal of clinical nutrition.87:12-22 - Increase in ghrelin levels after weight loss in obese Zucker rats is prevented by gastric banding.
Mariana P Monteiro, Andreia H Ribeiro, Ana F Nunes, Mónica M Sousa, J Duarte Monteiro, Artur P Aguas, M Helena Cardoso (2007) Obesity surgery.17:1599-607 - Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men.
Tina Akhavan, G Harvey Anderson (2007) The American journal of clinical nutrition.86:1354-63 - Gonadectomy and high dietary fat but not high dietary carbohydrate induce gains in body weight and fat of domestic cats.
Robert C Backus, Nick J Cave, Duane H Keisler (2007) The British journal of nutrition.98:641-50 - Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelin.
Kerry J Mackelvie, Graydon S Meneilly, Dariush Elahi, Alfred C K Wong, Susan I Barr, Jean-Pierre Chanoine (2007) The Journal of clinical endocrinology and metabolism.92:648-54 - Carob pulp preparation rich in insoluble dietary fiber and polyphenols enhances lipid oxidation and lowers postprandial acylated ghrelin in humans.
Sindy Gruendel, Ada L Garcia, Baerbel Otto, Corinna Mueller, Jochen Steiniger, Martin O Weickert, Maria Speth, Norbert Katz, Corinna Koebnick (2006) The Journal of nutrition.136:1533-8 - Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity.
Stefan O Krechowec, Mark Vickers, Arieh Gertler, Bernhard H Breier (2006) The Journal of endocrinology.189:355-63 - Influence of weight loss on plasma ghrelin responses to high-fat and high-carbohydrate test meals in obese women.
Monique Romon, Séverine Gomila, Pascale Hincker, Bruno Soudan, Jean Dallongeville (2006) The Journal of clinical endocrinology and metabolism.91:1034-41 - Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting.
Jean-Pierre Chanoine, Alfred C K Wong (2004) Endocrinology.145:3813-20
Somente para pesquisa, não é destinado ao uso terapêutico ou diagnóstico.
| Código do Produto | GHRT-89HK |
|---|---|
| Tipo de Produto | RIE Obesidade e Diabetes Grelina |
| Fornecedor | MILLIPORE |
| Quantidade | 125 tubos  |
| Espécie | Humano |
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