Leptina Humana - RIE
Human Leptin RIA
Informação: Leptina é sintetizada em adipócitos como uma molécula de 16 kDa e seus níveis circulantes são diretamente proporcionais a quantidade total de gordura corporal.
Aplicações: Overnight, incubação de equilibrio a 4°C. Volume de amostra de 100 µL para soro, plasma ou meio de cultura de tecido.
Reatividade: Humano
Precisão, %:
- Inter-ensaio: 3.6–6.2
- Intra-ensaio: 3.4–8.3
Áreas Terapêuticas:
- Diabetes
- Obesidade
- Desordens Metabólicas
Exatidão: 103–105%
Intervalo de Curva Padrão: 0.5–100 ng/mL
Especificidade:
Leptina Humana - 100%
Leptina de Rato - <0.2%
Leptina de Camundongo - <0.2%
Insulina Humana - Não Detectável
Peptídeo-C Humano - Não Detectável
Glucagon - Não Detectável
IGF-I - Não Detectável
Somatostatina - Não Detectável
PP - Não Detectável
Insulina de Rato - Não Detectável
Pró-Insulina Humana - Não Detectável
Leptina Canina - Não Detectável
Linearidade de Diluição: 88–101%
Desempenho:
- ED80 = 0.9 ± 0.1 ng/ml
- ED50 = 4.5 ± 0.4 ng/ml
- ED20 = 22.2 ± 2.8 ng/ml
DOCUMENTO
REFERÊNCIA DE PUBLICAÇÕES PARA ESTE KIT
- Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain.
Heidema AG, Wang P, van Rossum CT, Feskens EJ, Boer JM, Bouwman FG, Van't Veer P, Mariman EC (2010) Physiology & behavior.99:1-7 - Effect of overweight on gastrointestinal microbiology and immunology: correlation with blood biomarkers.
Tiihonen K, Ouwehand AC, Rautonen N (2009) The British journal of nutrition:1-9 - Appetite responds to changes in meal content, whereas ghrelin, leptin, and insulin track changes in energy availability.
Borer, Katarina T, et al. (2009) J. Clin. Endocrinol. Metab., 94: 2290-8 (2009) - Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase.
Elaine Tham, Jianhua Liu, Sheila Innis, David Thompson, Bruce D Gaylinn, Roberto Bogarin, Alon Haim, Michael O Thorner, Jean-Pierre Chanoine (2009) American journal of physiology. Endocrinology and metabolism.296:E1093-100 - Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial.
Dennis T Villareal, Krupa Shah, Marian R Banks, David R Sinacore, Samuel Klein (2008) The Journal of clinical endocrinology and metabolism.93:2181-7 - Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content.
E Louise Thomas, Elizabeth Potter, Isabella Tosi, Julie Fitzpatrick, Gavin Hamilton, Vian Amber, Robert Hughes, Christopher North, Paul Holvoet, Mary Seed, D John Betteridge, Jimmy D Bell, Rossi P Naoumova (2007) Atherosclerosis.195:e181-90 - Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.
Dennis T Villareal, Luigi Fontana, Edward P Weiss, Susan B Racette, Karen Steger-May, Kenneth B Schechtman, Samuel Klein, John O Holloszy (2006) Archives of internal medicine.166:2502-10 - Effect of short-term fasting on urinary excretion of primary lipid peroxidation products and on markers of oxidative DNA damage in healthy women.
Kyoung-Ho Lee, Helmut Bartsch, Jagadeesan Nair, Dong-Ho Yoo, Yun-Chul Hong, Soo-Hun Cho, Daehee Kang (2006) Carcinogenesis.27:1398-403 - Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene.
K Højlund, C Christiansen, K S Bjørnsbo, P Poulsen, L Bathum, J E Henriksen, O Lammert, H Beck-Nielsen (2006) Diabetes, obesity metabolism.8:322-30 - Serum haptoglobin: a novel marker of adiposity in humans.
C Chiellini, F Santini, A Marsili, P Berti, A Bertacca, C Pelosini, G Scartabelli, E Pardini, J López-Soriano, R Centoni, A M Ciccarone, L Benzi, P Vitti, S Del Prato, A Pinchera, M Maffei (2004) The Journal of clinical endocrinology and metabolism.89:2678-83 - Severe preeclampsia is associated with high inhibin A levels and normal leptin levels at 7 to 13 weeks into pregnancy.
Laurent J Salomon, Clarisse Benattar, François Audibert, Hervé Fernandez, Michel Duyme, Joëlle Taieb, René Frydman (2003) American journal of obstetrics and gynecology.189:1517-22 - Decreased maternal serum leptin in pregnancies complicated by preeclampsia.
T Laml, O Preyer, B W Hartmann, E Ruecklinger, G Soeregi, P Wagenbichler (2001) Journal of the Society for Gynecologic Investigation.8:89-93 - The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans.
H L Fehm, R Smolnik, W Kern, G P McGregor, U Bickel, J Born (2001) The Journal of clinical endocrinology and metabolism.86:1144-8 - Umbilical venous leptin concentration and gender in newborns.
T Laml, O Preyer, I Schulz-Lobmeyr, E Ruecklinger, B W Hartmann, P Wagenbichler (2001) Journal of the Society for Gynecologic Investigation.8:94-7 - Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women.
M Rendell, U L Hulthén, C Törnquist, L Groop, I Mattiasson (2001) The Journal of clinical endocrinology and metabolism.86:744-9 - Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy.
T Laml, B W Hartmann, E Ruecklinger, O Preyer, G Soeregi, P Wagenbichler (2001) Journal of the Society for Gynecologic Investigation.8:43-7 - Differences in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans.
M G McConway, D Johnson, A Kelly, D Griffin, J Smith, A M Wallace (2000) Annals of clinical biochemistry.37 ( Pt 5):717-23
Somente para pesquisa, não é destinado ao uso terapêutico ou diagnóstico.
| Código do Produto | HL-81K |
|---|---|
| Tipo de Produto | RIE Obesidade e Diabetes Leptina |
| Fornecedor | MILLIPORE |
| Quantidade | 250 testes  |
| Espécie | Humano |
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